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KMID : 0613819990090020201
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Journal of Life Science
1999 Volume.9 No. 2 p.201 ~ p.206
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Production of Nitric Oxide and Erythropoietin in Serum of Newborn
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Abstract
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Nitric oxide(NO) is a potent and selective pulmonary artery vasodilator. Erythropoietin(EPo) is produced in the kidney in response to reduced oxygen availability. In this study, blood samples were collected for determination of NO and EPO concentrations in 18 normal newborns and 16 newborns with respiratory distress syndrome(RDS). Serum was measured by Ding´s method for NO concentration and by enzyme-linked immunosorbant assay for EPO concentration. Nitrite ion concentration in serum was 14.9$\pm$3.2 $\mu$M in normal control group and 12.8$\pm$3.3 $\mu$M in RDS group. EPO concentration in serum was 16.2$\pm$3.4 mU/ml in normal control group and 21.2$\pm$5.4 mU/ml in RDS group. These results show the decrease of NO and increase of EPO in RDS newborn patients in comparison with normal newborns. Such imbalances may contribute to the development of several clinical symptoms.
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